Abstract: OBJECTIVE To investigate and analyze related influencing factors of patients with iron deficiency anemia (IDA) during pregnancy in Xiamen City and observe the intervention effect of iron proteinsuccinylate oral solution. METHODS A stratified cluster sampling method was used to select 926 pregnant women undergoing maternity check-ups from December 2018 to December 2019 as the research objects. According to whether the pregnant women had IDA, the subjects were divided into IDA groups(n=228) and non-IDA group(n=698), by comparing the medical records of the two groups of patients, clarify the risk factors of IDA during pregnancy, IDA patients were treated with iron proteinsuccinylate oral solution, and its effect on improving the iron deficiency and anemia status of the patients was observed. RESULTS The incidence rate of IDA during pregnancy of the enrolled subjects was 24.62%. Logistic regression analysis showed that the education level was junior high school and below, the farmers, the residence was rural, living in the new house, the annual family income was less than 80 000 yuan, the pregnancy period was more than 28 weeks, and frequently drinking coffee or tea, no iron and folic acid supplements, combined gastrointestinal diseases, postpartum, had history of abortion, frequently vomiting in early pregnancy were all risk factors for IDA in pregnant women(P<0.05). The Hb, RBC, MCV, MCH, MCHC and other red blood cell-related indicators and SI, SF, TAST and other iron metabolism indicators improved in IDA patients after treat with iron proteinsuccinylate oral solution significantly than before treatment(P<0.05). Among the included patients, 183, 41 and 4 patients were cured, effective and ineffective, respectively, and the effective rate was 98.25%. None of the 228 patients with IDA had gastrointestinal reactions or exacerbation. CONCLUSION Targeted prevention of the above risk factors, strengthen nutrition and health guidance during pregnancy, can avoid IDA during pregnancy and improve pregnancy outcome. In addition, the iron proteinsuccinylate oral solution has a good intervention effect on IDA during pregnancy, can significantly improve the body's iron deficiency and anemia state, while increasing the iron absorption rate, effectively avoiding the occurrence of gastrointestinal reactions, and its safety is high. It is worthy of clinical promotion.