Abstract: OBJECTIVE To improve the work efficiency and accuracy of the free examination of the subjects in the clinical trial process by building an information system which meet the actual management of the clinical trial in the hospital. METHODS Based on the existing physical examination management system and post payment mode of group examination in the hospital, the free examination management system of clinical trial was designed by using computer information technology and cooperation of multiple departments, so as to realize the free examination of subjects and the electronic settlement of expenses. RESULTS The system had low maintenance cost and flexible package design, which improved the compliance of free examination of subjects in the clinical trial, the ease of operation of researchers, the accuracy of examination cost settlement, and ensured the traceability of test data. CONCLUSION At present, the system runs smoothly, providing a reference example for the new organization in the early stage of work.