Abstract: OBJECTIVE To analyze the characteristics of platelet count abnormality(decrease or increase) induced by granulocyte colony stimulating factor(G-CSF) in order to provide references for its clinical rational drug use. METHODS MEDLINE, CNKI, Wanfang, VIP and CMB from the establishment of each database to January 7, 2021 were searched for platelet count abnormality induced by G-CSF, and the collected literatures were further analyzed statistically. RESULTS A total of 11 cases were identified and included in the analysis, all of which occurred during the period of using G-CSF. Among them, there were 8 males(72.7%) and 3 females(27.3%); aged from 4 days to 75 years old; 7 cases(63.6%) decreased and 4 cases (36.4%) increased; 8 cases(72.7%) had complications, most of which were thrombosis and bleeding events. The platelet count were significantly improved and the complications were resolved after withdrawal, reduction and symptomatic treatment in all cases. CONCLUSION Platelet count abnormality caused by G-CSF is relatively rare, and decrease is more common among them. The monitoring of platelet count should be strengthened during using G-CSF. Once platelet count abnormality occurs, G-CSF should be stopped and and symptomatic treatment should be given to reduce the risk of thrombosis or bleeding events.