Abstract: OBJECTIVE To introduce the anti-infective strategies and approaches made by clinical pharmacists for a case of an acute Stanford B aortic dissection patient appearing recurrent pulmonary infections preoperative and postoperative thoracic endovascular aortic repair(TEVAR), which provides reference for anti-infection of clinical similar cases. METHODS During the periods of anti-infective treatment, the clinical pharmacists participated in many consultations and whole-course pharmaceutical monitoring, and finally made the optimized anti-infection regimens together with clinicians according to the patient's clinical manifestations hospital bacterial epidemiological characteristics, the latest clinical guidelines, adverse effects caused by suspected drugs, and characteristics of pharmacokinetics/pharmacodynamics. RESULTS Clinical pharmacists' treatment recommendations were accepted by doctors and nurses, who adjusted their anti-infection treatment regimens. Under the active treatment and pharmaceutical monitoring, the patient's vital signs were greatly improved(including pulse rate, respiration rate, body temperature, and blood pressure). All infection indicators returned to be normal. The patient was discharged from hospital smoothly. CONCLUSION The clinical pharmacists give full play to their professional advantages in making and optimizing anti-infection regimens. In course of the treatment, they carry out pharmaceutical care and have successfully integrated into the treatment team with doctors and nurses as the core.