Abstract: OBJECTIVE To analyze the current hotspot of adverse events caused by immune checkpoint inhibitors(ICIs) for providing evidence on following research. METHODS Six data base were searched including PubMed, EMbase, CNKI, CBM, VIP and WanFang. Endnote was used to screen literatures. Bicomb was used to extract data and analyze publication year, magazine, document type, etc., and the word matrix of high-frequency topic words were generated. SPSS was used to take clustering analysis. RESULTS Two thousand three hundred and thirty three literatures were included in analysis. The most literature type and language were article and English. The top 10 publications were foreign journals. The top 3 journal on literature number were The Lancet Oncology, Immunotherapy and Journal of Clinical Oncology. Seven thousand and ninety one subject terms were obtained. High frequency terms were categorized to 9 dimension including various types of adverse events, serious adverse events(myositis and myocarditis), common adverse events(dermatotoxicity, hepatotoxicity and endocrine diseases), management of adverse events and using ICIs in combination with other therapies. CONCLUSION The number of literatures on adverse events caused by immune checkpoint inhibitors were increased rapidly since 2011, and most of journals have high impact factor. Current studies focus on manifestations and incidence of adverse events, the mechanism and relationship in serious adverse events and common adverse events, application of hormones in the management of adverse events, the regularity of adverse events when ICIs and chemotherapeutics are used in combination, and the effectiveness of treatment for patients related to ICIs adverse events.