Abstract: OBJECTIVE To identify the drug-related problems(DRPs) in the clinical application of proton pump inhibitors(PPIs) injection, and to provide reference for the standardized application of PPIs injection. METHODS The cases of using PPIs injection in Huainan Chaoyang Hospital from July to December 2019 were collected and sorted out. The DRPs of PPIs injection was identified and analyzed by Granada-Ⅱ classification of drug related problems in Spain which was widely used in the world. RESULTS DRPs were found in 417 cases of PPIs injection, with a total of 947 DRPs. They were mainly 527 DRP5 accounting for 55.65%, 321 DRP2 accounting for 33.89%, 62 DRP6 accounting for 6.55% and 37 DRP4 accounting for 3.91%. The main manifestations of DRP5 were the drugs with taboos were not flushed and the route of administration was unreasonable and so on. DRP2 showed that there was no indication for the use of drugs. DRP6 was characterized by adverse drug interaction, long course of preventive medication and so on. DRP4 showed that the course of treatment was too short. CONCLUSION In view of the DRPs existing in the clinical application of PPIs injection, clinical pharmacists should formulate corresponding drug use rules to assist hospitals to strengthen the application management of PPIs injection, improve the level of rational drug use and ensure medical safety.