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    加味酸枣仁汤与劳拉西泮对高中生焦虑症的疗效以及安全性比较

    Comparisons of the Efficacy and Safety Between Jiawei Suanzaoren Decoction and Lorazepam for Anxiety Disorder Treatment in Senior High School Students

      摘要
    • 摘要: 目的 比较加味酸枣仁汤与劳拉西泮治疗高中生焦虑症的疗效以及安全性。方法 高中生焦虑症患者68例随机分为加味酸枣仁汤组和劳拉西泮组，并给予相应的治疗。于0，1，2周测定汉密尔顿焦虑量表（Hamilton Anxiety Scale，HAMA）得分评价其疗效，第2周测定副反应量表（Treatment Emergent Symptom Scale，TESS）评价其不良反应。比较2组间HAMA减分率、治疗有效率、起效时间、不良反应发生率的差异。结果 1，2周，2组HAMA得分均显著下降（P<0.001）。虽然2组总有效率无统计学差异（90.91% vs 90.63%），但是加味酸枣仁汤组疗效显著的比例（57.58%）明显高于对照组（31.25%）（P<0.05），且HAMA得分（10.82±5.80）显著低于对照组（14.88±5.50）（P<0.05）。加味酸枣仁汤组起效时间（3 d）则稍晚于对照组（1 d）（P<0.01）。加味酸枣仁汤组乏力和头痛的反应发生率显著低于劳拉西泮组（P<0.05）。结论 在高中生焦虑症的治疗中，加味酸枣仁汤比劳拉西泮更安全、有效。

       

      Abstract: OBJECTIVE To compare the efficacy and safety between Jiawei Suanzaoren decoction and lorazepam for anxiety disorder treatment in senior high school students.METHODS The 68 cases of senior high school students with anxiety disorder were randomly assigned to the Jiawei Suanzaoren decoction group and the lorazepam group, and then given the corresponding treatments. The scores of Hamilton Anxiety Scale(HAMA) in week 0, 1, 2 were measured for determining the treatment efficacy, and Treatment Emergent Symptom Scale(TESS) in week 2 was tested for assessing the adverse effects. HAMA score reduction rates, effectiveness rates, onset time and adverse effect incident rates were compared between two groups. RESULTS The HAMA scores in week 1, 2 were both obviously decreased in both two groups(P<0.001). Although the total effectiveness rates had no statistically different between two groups(90.91% vs 90.63%), the Jiawei Suanzaoren decoction group had a higher marked effectiveness rate(57.58%) and a lower HAMA score(10.82±5.80) than those of the control group(31.25%, 14.88±5.50)(P<0.05). The onset time in the Jiawei Suanzaoren decoction group(3 d) was longer than the control group(1 d)(P<0.01). The fatigue and headache incident rates in the Jiawei Suanzaoren decoction group were significantly lower than those of the lorazepam group(P<0.05). CONCLUSION Jiawei Suanzaoren decoction is safer and more effective than lorazepam for the anxiety disorder treatment in senior high school students.

       

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