Abstract: Migraine is a common clinical neurological disease, which seriously affects the quality of work and life of patients.Therefore, the prevention and treatment of migraine has important practical significance.Studies have shown that Chuanxiong Rhizoma-Gastrodiae Rhizoma has obvious effects on migraine patients, and modern pharmacological studies have found that its main active ingredients are ferulic acid, ligustrazine, ligustic acid lactones, gastrodin, gastrodigenin, etc.However, the material basis and mechanism of its treatment of migraine have not yet been elucidated.In this paper, by reviewing the relevant literature reports of Chuanxiong Rhizoma-Gastrodiae Rhizoma at home and abroad, it summarizes the effective material basis and mechanism of action for the prevention and treatment of migraine, providing a theoretical basis for clinical application.