Abstract: OBJECTIVE To implement the requirements of Hebei Provincial Health Commission “Guidelines for the Selection, Evaluation and Management of Drug Catalogue in Public Medical Institutions in Hebei Province”, and provide evidence-based evidence for hospital decision makers to select and use Macrolide antimicrobials in clinical rationality.METHODS According to the 100-point scoring system and referring to the drug instructions, clinical guidelines and literature, the hospital health technology of oral macrolides antibacterial drugs in Hebei General Hospital was evaluated from six aspects, including safety, efficacy, economy, innovation, suitability and accessibility.RESULTS The final scores of erythromycin enteric-coated capsules, azithromycin suspension, azithromycin tablets and clarithromycin tablets were 71, 78, 83 and 68.5, respectively.Azithromycin was recommended by multiple guidelines and expert consensus, and has certain advantages in the treatment of community-acquired pneumonia and mycoplasma pneumonia.Both azithromycin suspension and azithromycin tablets were original varieties with small economic advantages, but they are widely used worldwide and have high safety.Erythromycin enteric-coated capsules had advantages in terms of chlamydia infection, and the price was relatively low.However, the drug was a domestic product and has not passed the consistency evaluation, and has less clinical application.Clarithromycin tablets had a good effect on simple obstructive pulmonary disease and chronic sinusitis.In addition, clarithromycin has a place in the quadruple regimen against Helicobacter pylori.This variety was a domestic variety and has passed the consistency evaluation.But the safety of clarithromycin was no better than other macrolide drugs, and its clinical application was limited.In addition, a variety of hepatic microsomal enzyme inducers or inhibitors could interact with macrolide drugs, and medical staff should pay attention to the impact of drug interactions during application.CONCLUSION The health technology assessment provides an evidence-based basis for hospital selection and rational use of macrolides.Clinicians can reasonably choose the drugs based on the patient’s conditions and needs.Attention should be paid to drug interactions to prevent adverse events when combined with other drugs.