Abstract: OBJECTIVE To improve the dissolution time of berberine tannate pellicles by controlling the synthetic material of berberine tannate.METHODS After separation and extraction of 73% crude tannic acid with different polar solvents, different fractions of tannic acid were obtained and reacted with berberine hydrochloride to prepare berberine tannate.Then, the dissolution time of each coating was detected to find the best fraction of tannic acid as the raw material for the synthesis of berberine tannate pellicles.RESULTS The berberine tannate prepared from the water fraction of tannic acid and the remaining water fraction as raw materials shortened the dissolution time of berberine tannate pellicles to <5 min, which fully met the requirements of pellicles of Chinese Pharmacopoeia 2015 Edition.CONCLUSION The berberine tannate active pharmaceutical ingredient produced after the process optimization can shorten the dissolution time of berberine tannate pellicles significantly and improve the dispersive property of film agent.