Abstract: Rifampicin(RFP) acts as a front-line anti-tuberculosis drug, which is mainly metabolized by the liver, with liver injury as common adverse reactions during anti-tuberculosis treatment. At present, a variety of traditional Chinese medicine shows a clear poison reduction effect, but the mechanism of action is not clear. This paper explores the toxicological mechanism of RFP liver injury from the aspects of metabolic disorder, oxidative stress, inflammation and apoptosis, and reviews the research progress of liver injury prevention and treatment with RFP combined with traditional Chinese medicine in order to provide reference for clinical prevention and treatment and related basic research.