Abstract: OBJECTIVE To establish a pharmaceutical monitoring system for rheumatoid arthritis with Lugua polypeptide injection with the help of hospital information construction platform. METHODS Increased the dialectical records of traditional Chinese medicine(TCM) in electronic medical records, and introduced TCM four diagnostic instruments to help dialectical TCM. Reinforced the examination of solvents in informationized trials, and supervised the process of preparation and distribution. A digital doctor-patient communication platform was used to return visits to 200 patients discharged from rheumatoid arthritis treated with Lugua polypeptide injection in the rheumatology department. The medication monitor-ring service was extended outside the hospital, and timely feedback was provided to the departments of medical and nursing to improve quality. RESULTS The diagnostic accuracy rate of Lugua polypeptide injection in the treatment of rheumatoid arthritis was improved. The rate of unreasonable medical orders decreased from 54.44% to 27.00%, and the number of overtime delivery cases decreased from 21 to 10, and the patient satisfaction with pharmacy return visits increased from 90.82% to 95.91%. CONCLUSION The establishment of a pharmaceutical monitoring system for Lugua polypeptide injection requires a combin-ation of TCM syndrome differentiation and modern information methods. It is based on the syndrome differentiation, and it need to carry out diversified, three-dimensional and information-based monitoring, then establish and improve the supervision and assessment mechanism, standardize medication behaviors, ensure medication safety, and improve patient satisfaction.