Abstract: Candida albicans is the most common isolated strains in clinical Candida infection, which can cause superficial infection and even life-threatening deep infection. In recent years, studies on the drug treatment of Candida albicans infection have been kept doing, new functional targets have been deeply studied, and some new antifungal compounds have been found. This study briefly reviewed the pathogenic and drug-resistance mechanism of Candida albicans, aimed at providing a new research strategy for the treatment of clinical Candida albicans infection.