Abstract: The increasing studies have shown that metabolic inflammation caused by obesity is the main cause of insulin resistance and a series of complications. Adipose tissue is the main place for the initiation and occurrence of metaflammation, and the exosomes secreted by adipose tissue is not only an important medium for communication between adipose and other tissues and organs, but also an significant regulator of metaflammation. This paper introduced the composition and biological function of exosomes secreted from adipose tissue, and especially to summary the role and mechanism of these exosomes in the occurrence and development of metaflammation caused by obesity.