Abstract: OBJECTIVE To explore the rules of the prevention and medical observation period in the Guidance of treatment for Corona Virus Disease 2019(COVID-19), the guidance of traditional Chinese medicine(TCM) prevention and treatment for COVID-19 and health care guidelines of TCM for COVID-19, so as to provide reference for prevention and control of COVID-19. METHODS Collected the guidance for the prevention and control of COVID-19 in various regions of the country before October 11, 2020, and entered the applicable population, staging, Chinese patent medicines, prescription names and prescription composition of the prevention period and medical observation period into the Excel table, and these after the data was collated, it was imported into the ancient and modern medical case cloud platform V2.2.2 software to analyze the association rules and cluster analysis of TCM prescriptions. RESULTS Analysis of the 66 guidance of prevention and medical observation period medication guidance issued by the country and provinces, the most frequently used Chinese patent medicine was Huoxiangzhengqi liquid. The top 5 TCMs in the prevention period were Astragali Radix, Glycyrrhizae Radix et Rhizoma, Lonicerae Japonicae Flos, Atractylodis Macrocephalae Rhizoma and Pogostemonis Herba. Frequent analysis of prescription TCMs were mostly cold, sweet, bitter and spicy, and were mainly attributed to the lungs, stomach and spleen. Analysis of association rules yields a series of related drug combinations mainly based on "Atractylodis Macrocephalae Rhizoma-Saposhnikoviae Radix" "Saposhnikoviae Radix-Astragali Radix" "Platycodonis Radix-Glycyrrhizae Radix et Rhizoma". Five clustering results were obtained by cluster analysis in the medical period such as "Platycodonis Radix-Astragali Radix-Atractylodis Macrocephalae Rhizoma-Saposhnikoviae Radix-Glycyrrhizae Radix et Rhizoma". The top 5 TCMs in the medical observation period were Atractylodis Rhizoma, Pogostemonis Herba, Lonicerae Japonicae Flos, Citri Reticulatae Pericarpium, Glycyrrhizae Radix et Rhizoma. Frequency analysis of prescription of TCMs was mostly warm, spicy, sweet, and bitter. Analysis of association rules yields a series of related drug combinations mainly based on "Atractylodis Rhizoma-Pogostemonis Herba" "Pogostemonis Herba-Citri Reticulatae Pericarpium" "Zingiberis Rhizoma Recens-Pogostemonis Herba". Four clustering results were obtained by cluster analysis in the medical period such as "Atractylodis Rhizoma-Zingiberis Rhizoma Recens-Pogostemonis Herba-Citri Reticulatae Pericarpium". CONCLUSION The drugs used in the preventive period are mainly heat-clearing drugs, Qi-invigorating drugs and aromatized wet drugs, with the purpose of strengthening the body and eliminating evils, and adjusting the biased state of physique from two aspects of strengthening and protecting righteousness and dispelling cold and dampness to achieve the best preventive effect. During the observation period, the patients were treated with aromatized wet drugs, heat-clearing medicine, the drug of relieving phlegm and relieving cough and the drug of regulating Qi to dispel dampness and cold from three aspects:dispelling lung and cold, clearing heat and detoxification, and regulating qi and dampness.