Abstract: OBJECTIVE To study the effects of activated carbon N-acetylcysteine microcapsule(ACNAC) on hemorheological parameters in SD rats with non-alcoholic fatty liver disease. METHODS The non-alcoholic fatty liver disease model of rats was established by the means of high-glucose-high-fat diet in 10 weeks. Then the rats were treated with low, medium and high doses(20, 40, 80 mg·kg^-1) of ACNAC, N-acetylcysteine at a dose of 80 mg·kg^-1 and polyene phosphatidyl choline at a dose of 100 mg·kg^-1. After 10 weeks, blood rheology and blood fat were measured and the pathological changes of liver tissues were observed simultaneously. RESULTS The hemorheological parameters, triglyceride(TG) and cholesterol(TC) in model group were increased significantly compared with normal group(P<0.05). After treatment, the level of TC, TG was significantly reduced in high doses of ACNAC group compared with model group(P<0.05) and which were superior to N-acetylcysteine group. Furthermore, the whole blood viscosity in high shear, the shear, low shear, hematocrit and plasma viscosity were also reduced in high doses of ACNAC group compared with model group(P<0.05). In addition, high shear and low shear of the high doses of ACNAC group were lower than those of N-acetylcysteine group and polyene phosphatidyl choline group(P<0.05). The results of HE pathological showed that the liver pathological injury of SD rats treated with ACNAC was significantly improved. CONCLUSION ACNAC can reduce the level of blood lipid and hemorheology in rats with non-alcoholic fatty liver disease in different degrees.