Abstract: OBJECTIVE To summarize the pharmacological mechanism of everolimus and to explore the effect of monotherapy or combined therapy of malignant tumors of female genital organs, and to provide a novel therapeutic ideas for patients with advanced stage, recurrence and metastasis. METHODS Retrieval of relevant literatures published in PubMed, Medline, CNKI, Wanfang and VIP databases on everolimus in the treatment of cervical cancer, ovarian cancer and endometrial cancer was conducted, and the current clinical situation was reviewed. RESULTS Everolimus can inhibit the growth, metabolism and angiogenesis of tumor cells through various ways, which plays a significant role in antitumor effects. Everolimus may overcome drug resistance and enhance tumor sensitivity to treatment, especially when combined with chemotherapy, radiotherapy, hormone therapy and other molecular targeted drugs. CONCLUSION Everolimus has promising prospects in advanced as well as advanced stage, recurrent and metastatic malignant tumors of female genital organs, with a great potential for improving patients’ clinical outcomes.