Abstract: siRNA shows great prospect in the treatment of human diseases, especially malignant tumors with its targeted selectivity and pathogenic gene down-regulation. In order to enhance the targeting and therapeutic effectiveness of siRNA delivery systems, many vectors have been extensively studied. Exosomes is a promising siRNA delivery carrier which exists in the endogenous system of the body, with advantages of high biocompatibility, low immunogenicity and active targeting, etc. In this paper, the advantages and disadvantages of the exosome siRNA delivery system, the way siRNA is loaded into exosomes, and the exosome-mediated targeted delivery of siRNA and its application are reviewed, aiming to provide reference for the study of exosomes as a new targeting carrier for siRNA delivery system.