Abstract: OBJECTIVE To investigate the effects of sodium dodecyl sulfate(SDS) from different sources on in vitro dissolution of febuxostat tablets and provide ideas for its quality control. METHODS Perform the dissolution test with paddles, using 900 mL of SDS solution with different concentration as the dissolution media, the rotational speed was 50 r·min^-1. Continuous filtrate was determined by UV spectrophotometry and dissolution curve was determined at 315 nm. RESULTS Different sources SDS had different effects on the dissolution behavior of febuxostat tablets. Using the similarity factor method to evaluate the similarity of dissolution behavior between them, the dissolution behavior could be divided into two categories. CONCLUSION By using SDS as dissolution medium, it is necessary to define its components in order to ensure the durability of dissolution method, so as to control the quality of drugs.