Abstract: Myocardial fibrosis, a common clinical disease, can lead to sudden cardiac death, arrhythmia and heart failure. Thus, developing effective therapeutic drugs are critical important. In recent years, a large number of studies have shown that natural products have great potential in the prevention and treatment of myocardial fibrosis. This paper reviewed the advance of the natural products in the treatment of myocardial fibrosis, which will provide useful information for the exploration of lead compounds against myocardial fibrosis and the in-depth research and development of natural products.