Abstract: OBJECTIVE To introduce the major updates and revisions of the specifications of chemical drugs in Chinese Pharmacopoeia 2020 Edition(ChP 2020), and help the readers to understand and implement the ChP 2020. METHODS To give an introduction of the selection of the chemical drug monograph, standardization of drug generic names and mainly revisions of the specifications of chemical drugs, a numerical example was also given to illustrate the revisions. RESULTS The ChP 2020 had developed more rigorous standards for chemical drugs, variety selection was more reasonable, it had a better coordination with international drug standards, and the standard formation mechanism was more scientific. CONCLUSION ChP 2020 will play an important role on strengthening the quality and ensure the safety and effectiveness of public medication of the chemical drugs.