Abstract: The effectiveness of lopinavir/ritonavir, an oral antiviral drug, was affected by patient's sex, race, presence of comorbidities, adherence. Interactions with other drugs was also one of the important factors affecting the antiviral action of lopinavir/ritonavir, the interactions among lopinavir/ritonavir and some antibacterials were major, complex and delayed. Thus, the choice of antibacterials and concentration monitoring were very important for the patient with bacterial or fungal infections receiving lopinavir/ritonavir treatment. This review summarized the data about the influence of antibacterials on lopinavir/ritonavir treatment and analyzed interaction mechanisms and suggested management to provide reference about choice of antibacterials and dosage adjustment of antibacterials, to avoid the risk of medication and improved safety.