Abstract: OBJECTIVE To introduce the content and model of clinical pharmaceutical service of organ transplantation in the United States and to provide reference for improving it in China. METHODS The content and model of clinical pharmaceutical service were summarized by visiting the daily work of clinical pharmacists in organ transplantation center of the United States, the shortcomings of domestic pharmaceutical service in China were analyzed. RESULTS The whole process of clinical pharmaceutical service for donors and recipients from pre-operation to post-operation was covered in the United States, it was also homogeneous and refined, which was quite different in China. CONCLUSION The content and model of clinical pharmaceutical service in organ transplantation of the United States is worth learning and applying, domestic pharmacists should actively expand the content and model of service, and gradually improved the pharmaceutical service.