Abstract: OBJECTIVE To comb the development trend of global selenium medicine technology patents, and provide reference for Chinese selenium medicine technology research and development innovation, market development, patent application and protection. METHODS The paper summarized and analyzed the progress of patents by literature research method, patent analysis method and text mining method. RESULTS & CONCLUSION Selenium medicine technology patents show an overall growth trend, involving metabolic diseases, nervous system diseases, anti-tumor and so on. Anti-tumor drugs are the current research hotspots, and foreign institutions have been focusing on the layout. China needs to further promote biochemical, physiological, clinical and mechanism research.