Abstract: OBJECTIVE To explore the anti-liver fibrosis mechanism of celery seed through establishing the active components-targets network and protein interactions network and analyzing the functions and pathways of targets. METHODS The active ingredients of celery seed were obtained by TCMSP, literature study and previous work of the laboratory which author study in. SwissTargetPrediction and BATMAN-TCM databases were used to obtain the targets of constituent, GeneCards and OMIM databases were used to predict and screen the targets associated with liver fibrosis. The Cytoscape software was used to construct the active components-targets network. The protein-protein interaction network was constructed by using the String database and Cytoscape software. The GO and KEGG pathways involved in the targets were analyzed by DAVID, and the mechanism of anti-liver fibrosis of celery seed was analyzed in combination with relevant literatures. RESULTS The results showed that 17 active components and 69 targets of celery seed were involved. The network results showed that celery seed was mainly involved in the process of collagen catabolic, inflammatory response and negative regulation of cholesterol storage, by adjusting the TGF-β1, NF-κB, PI3K/AKT and other signaling pathways to exert anti-liver fibrosis effect. CONCLUSION This study reflects the characteristics of multicomponent, multitarget and multipathway of celery seed, and multiple signaling pathways which it act on are correlated with each other, providing new ideas and methods for further research.