Abstract: OBJECTIVE To discuss the characteristics of clinical medication and regularity of formula construction in treatment of chronic refractory wound with removing slough and promoting growth of tissue regeneration based on data mining. METHODS The databases including CNKI, Wanfang and VIP database were retrieved for searching the documents about treatment of chronic refractory wound with removing slough and promoting growth of tissue regeneration and establishing a database of traditional Chinese medicine formulas and medicinals. The study on the documents was conducted through frequency statistics, association rules analysis and system cluster analysis. RESULTS There were 117 formulas and 1 012 times of the total use frequency included involving 151 medicinals and 50 high-frequent medicinals as followed Draconis Sanguis, Borneolum Syntheticum, Olibanum, Myrrha, Angelicae Sinensis Radix, Phellodendri Chinensis Cortex, etc. The pulling out poison and removing the rotten, promoting blood circulation to remove blood stasis and clear heat and detoxification drugs accounted for the highest percentage. In the study of medicinal properties, Siqi were mainly cold and warm. The five flavors were mainly bitter, sweet, pungent. There were more drugs in the heart meridian, liver and lung meridian. The commonly use dosage forms were paste. There were 29 binomial correlations and 13 trinomial correlations obtained from association rules analysis. There were 9 combinations obtained from clustering analysis. CONCLUSION Modern clinical use of traditional Chinese medicine for the treatment of chronic refractory wounds use the principle of removing saprophylaxis as a symbol, and base on the treatment of stasis and toxic. Its emphasis is placed on the compatible use of the drugs of the sorts of activating blood circulation and removing blood stasis as well as heat-clearing and detoxification drugs.