Abstract: OBJECTIVE To explore the therapeutic effect of Loquat leaf extract on asthma mice model. METHODS Sixty BALB/c mice were randomly divided into 6 groups, blank group, model group, Loquat leaf extract low, medium and high dose groups(50, 100, 150 mg·kg^-1), dexamethasone group(0.5 mg·kg^-1, positive control). Ovalbumin(OVA) induced asthma mouse model, each group of mice were gavaged with corresponding drugs. The airway hyperresponsiveness of mice was detected 24 h after the last OVA modelling. The number of inflammatory cells in bronchoalveolar lavage fluid was counted by Wright-Giemsa staining classification. The levels of Eotaxin, IL-4, IL-5, IL-13 and OVA-specific IgE(OVA-sIgE) were detected by ELISA. HE and AB-PAS staining were used to observe the pathological changes of mice lung tissue. Western blotting was used to detect the expression of AKT, p-AKT, PI3K and Cyclin D1 in lung tissue. RESULTS Loquat leaf extract(100, 150 mg·kg^-1) could effectively reduce the number of inflammatory cells including eosinophils, macrophages, lymphocytes, and neutrophils; reduce the expression levels of Eotaxin, IL-4, IL-5, IL-13 and OVA-sIgE; inhibit the infiltration and mucus secretion of inflammatory cells in the lung tissue of asthmatic mice; inhibit the protein expression of AKT, p-AKT, PI3K and Cyclin D1 in asthma models. CONCLUSION Loquat leaf extract has a good inhibitory effect on OVA-induced airway inflammation in asthma, which can provide a reference for the study of Loquat leaf in the treatment of asthma.