Abstract: OBJECTIVE To optimize the extraction technology of Compound Roucongrong mixture. METHODS Based on single factor experiments, set liquid-to-material ratio, extraction time and soaking time as independent variable, and the comprehensive score of the content of verbascoside, lobetyolin and salvianolic acid B as the response value. The 3-factor 3-level Box-Behnken response surface methodology was used to determine the optimal extraction process, and analytic hierarchy process(AHP) was adopted to determine the weight coefficient. RESULTS The optimal extraction technology was as follows: liquid-to-material ratio was 10：1, soaking for 1.8 h, extracting twice and 3.0 h each time. Under the optimum extraction technology conditions, comprehensive score was 95.960 3, which was closed to the predictive value of the model. CONCLUSION The weight coefficient determined by AHP is objective, real and can reflect the compound compatibility information. The optimized extraction technology is simple, convenient, stable and feasible, which can provide reference for mass production of Compound Roucongrong mixture.