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    ZnO@ZnFe2O4乳膏的制备工艺及皮肤用药安全性评价

    Preparation Progress of ZnO@ZnFe2O4 Cream and Its Safety Evaluation of Skin Medication

      摘要
    • 摘要: 目的 研究ZnO@ZnFe2O4乳膏的制备工艺及皮肤用药的安全性。方法 采用正交试验方法优选ZnO@ZnFe2O4乳膏的成型工艺；采用Buehler试验，观察豚鼠皮肤接触ZnO@ZnFe2O4乳膏后的过敏情况；将ZnO@ZnFe2O4乳膏单次或多次涂于新西兰兔完整及破损皮肤处，观察药物对皮肤的刺激情况；新西兰兔皮肤单次给药观察药物的急性毒性。结果 ZnO@ZnFe2O4乳膏的最佳工艺条件：乳化剂的用量为6%，乳化时间为20 min，搅拌速度为1 600 r·min-1，乳化温度为80℃；采用最佳工艺制备的ZnO@ZnFe2O4乳膏对豚鼠皮肤未产生致敏反应，对兔皮肤未产生刺激性，对兔皮肤未引起急性毒性反应。结论 ZnO@ZnFe2O4乳膏经皮给药安全可靠。

       

      Abstract: OBJECTIVE To study the preparation progress and safety of skin medication of ZnO@ZnFe2O4 cream. METHODS Optimizing molding technology of ZnO@ZnFe2O4 cream was optimized by orthogonal experiment method. Buehler test was performed for evaluating the degree of allergy in guinea pig after skin contact with ZnO@ZnFe2O4 cream. Skin irritation was monitored by applying ZnO@ZnFe2O4 cream on the intact and wounded skin of rabbits in single or multiple times. Single administration was given to observe the acute toxicity of ZnO@ZnFe2O4 on New Zealand rabbits. RESULTS The optimized condition was shown below: emulsifier dosage was 6%, emulsifying time was 20 min, stirring speed was 1 600 r·min-1, emulsifying temperature was 80 ℃. The optimized progress producted-ZnO@ZnFe2O4 cream wasn't caused allergy in guinea pig, also wasn't caused side effects and acute toxicity in rabbits' skin. CONCLUSION Transdermal administration is a safety way for ZnO@ZnFe2O4 cream.

       

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