Abstract: OBJECTIVE To prospectively study the clinical efficacy of nifedipine sustained release tablet combined with labetalol in the treatment of patient with hypertension disorder complicating pregnancy and its effect on serum leucineaminopeptidase(LAP) and adiponectin(APN) levels. METHODS The 120 patients with hypertension disorder complicating pregnancy admitted to Affiliated Hospital of Chengde Medical College from September 2017 to June 2019 were selected and divided into observation group and control group by random number table method, with 60 cases in each group. Patients in the control group were treated with labetalol, while patients in the observation group were treated with nifedipine sustained release tablets orally on the basis of the control group for 10 d. The differences in systolic blood pressure and diastolic blood pressure, plasma viscosity and 24 h urine protein content before and after treatment were compared between the two groups. The occurrence of adverse reactions in the treatment process was counted and the effect of treatment on pregnancy outcome was detected. RESULTS After treatment, the total effective rate was 91.67% in the observation group and 73.33% in the control group. The blood pressure of the two groups decreased significantly(P<0.05), and the difference between the two groups was statistically significant(P<0.05). All the indicators of the two groups were significantly improved(P<0.05), and the efficacy of the observation group was significantly better than that of the control group(P<0.05). The pregnancy outcomes of the two groups were monitored. The rate of preterm delivery in the observation group combined with nifedipine sustained release tablets was lower than that in the control group(P<0.05). The natural birth rate was higher than the control group(P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups. CONCLUSION Nifedipine sustained-release tablets combined with labetalol has a good effect in the treatment of hypertension disorder complicating pregnancy, and after treatment, it can effectively reduce the serum levels of high-sensitivity C-reactive protein and homocysteine, reduce the damage of inflammation on the vascular wall, and improve LAP and APN levels, it can also reduce endothelial dysfunction, dilate arterioles, reduce blood pressure and risk of premature delivery, and improve pregnancy outcomes of the patients. It has the significance of further exploration.