Abstract: OBJECTIVE To explore the best extraction technology of Bailian vaginal suppository contents. METHODS Based on the content of dry paste rate, scutellarin, matrine, and momordin Ic, the influence of dissolution dose, extraction time and extraction times on the extraction effect of vaginal suppository contents were investigated by using analytic hierarchy process to determine the weight coefficient and orthogonal design method. RESULTS The best extraction technology for Bailian vaginal suppository contents was as follows: with ten times the amount of water, and boiling three times for 0.5 h each time. CONCLUSION The optimized extraction technology is feasible, it can objectively reflect the prescription compatibility information, and reproducible well, it can provide reference for the industrial production of Bailian vaginal suppository.