Abstract: OBJECTIVE To observe the clinical efficacy of Houttuynia granules combined with Cefprozil tablets in the treatment of patients with acute tonsillitis, and to analyze its effects on cytokines and immune function. METHODS The 240 patients with acute tonsillitis were diagnosed definitely from January to November 2018 in Jiaxing Hospital of TCM. The patients were divided into treatment group and control group by random number table method. The treatment group was treated with Houttuynia granules and Cefprozil tablets, while the control group was only treated with Cefprozil tablets by oral. After 3 days of treatment, the clinical efficacy and total treatment efficiency were analyzed. The expressions of serum interleukin-6(IL-6), tumor necrosis factor-α(TNF-α) and interferon-β(IFN-β), and peripheral blood CD4⁺, CD8⁺ T lymphocytes and CD4⁺/CD8⁺ levels were compared before and after treatment. RESULTS In the treatment group, the time of body temperature recovery, tonsil swelling and cough duration was (1.84±0.23), (1.96±0.36), (2.17±0.43)d, respectively, which were significantly less than the control group(P<0.01). The total treatment efficiency was 89.2%, it was significantly higher than that of the control group(P< 0.01). The levels of serum cytokines IL-6, TNF-α and IFN-β in the treatment group were significantly lower than those of before treatment and the control group(P<0.05). The CD4⁺, CD8⁺ levels and CD4⁺/CD8⁺ values in the peripheral blood of the treatment group were significantly higher than those of before treatment and the control group(P<0.05). CONCLUSION The combination Houttuynia granules with Cefprozil tablets can significantly shorten the clinical course of acute tonsillitis, ameliorate clinical symptoms and inflammatory damage, and improve immune function.