Abstract: OBJECTIVE To discuss the function of clinical pharmacists in identifying sensitizing drugs, formulating and adjusting of glucocorticoid administration scheme, preventing and handling the waterfall effect of adverse reactions in the treatment of moderate toxic epidermal necrolysis METHODS The clinical pharmacists participated in the treatment of one toxic epidermal necrolysis case, screened the drugs that the patients had taken before and after being hospitalized, compared the Naranjo's scores and ALDEN scores, and finally determined that the sensing drug was likely to be fluconazole. At the same time, the pharmacists adjusted the administration method and dosage of glucocorticoid and human immunoglobulin according to the patient's clinical symptoms, laboratory examination indicators and drug characteristics to control the allergic symptoms. It was suggested to add the calcium carbonate D3 tablets and potassium chloride sustained release tablets to stabilize the electrolyte level, adopt omeprazole enteric-coated capsules to protect the gastric mucosa, and add human serum albumin to improve the hypoproteinemia. The pharmacists also conducted pharmaceutical care for complications such as skin infection, oral candidiasis and bacteremia. RESULTS The patient got improved after the treatment. The patient left the hospital after the clinical symptoms became stable. CONCLUSION By participating in the treatment of toxic epidermal necrolysis, the clinical pharmacists assisted the doctors to prepare and adjust the therapy, and administrated the drugs according to the therapeutic evaluation, complications supervision and safety monitoring, so that they ensured the safety and effectiveness of the treatment for patient.