Abstract: OBJECTIVE To evaluate whether medication therapy management(MTM) has economic benefits through cost-benefit analysis by apply standardized process of MTM to patients. METHODS Applying MTM service model in pharmaceutical care for patients, organizing and recording the general condition, the disease and medication situation, and the cost of medicine of patients, discovering and analyzing the patients' problem of using medicine and lifestyle, proposing the drug treatment plan. Finally, archiving and following up the patients' data. The cost was the cost of MTM services, the benefit indicator was the reduction of drug costs, and calculated the cost-benefit ratio before and after the service. RESULTS The clinical pharmacist performed MTM service on 80 patients, and finally completed 59 cases. The ratio of male to female was 39:20, the average age was (62.39±15.75) years old, using 446 kinds of drugs, and the average kinds of drugs were (7.56±3.77). Two hundred and fifty-five cases were intervened and the success rate of intervention was 73.33%. The cost of medication before and after service was statistically analyzed as two groups. It was found that the cost of medication after intervention was significantly lower than that before intervention(P<0.05), and the cost-benefit ratio was 4.25>1. CONCLUSION Clinical pharmacists' MTM services can improve patients' compliance, improve medication problems and lifestyle, and provide positive economic impact to patients.