Abstract: In recent years, cardiovascular and cerebrovascular diseases caused by atherosclerosis(AS) have become one of the main causes of human death in the worldwide. According to relevant studies, hypertension, high blood fat, obesity, smoking and other factors are closely related to the occurrence of AS. As an extremely dangerous factor in the development of AS, oxygenated low density lipoprotein(ox-LDL) can promote the formation of AS by inducing a series of pathophysiological changes in the body. A large number of studies have found that isorhamnetin(ISO), an important monomer of sea buckthorn flavonoids, have much cardiovascular protective effects, such as anti-oxidation, protection of endothelial cell barriers, inhibition of adhesion between endothelial cells and monocytes, reduction of lipid deposition, inhibition of proliferation and migration of vascular smooth muscle cell, and anti-thrombosis. Then, ISO could play a significant role in the prevention and treatment of AS. Based on the occurrence mechanism of AS, this paper summarizes the anti-atherosclerosis effects of ISO in the pathophysiology process of AS.