Abstract: OBJECTIVE To optimize the extraction process of volatile oil from Artemisia argyi. METHODS Artemisia argyi was extracted by water extraction coupling rectification, and the yield of volatile oil was calculated. The contents of the main effective components of eucalyptol was determined by GC. The information entropy principle was applied to analyze the weight of the volatile oil yield and the contents of eucalyptol, and the comprehensive score M was obtained as the evaluation index. The best extraction process was obtained by Box-Behnken model analysis of M. RESULTS The optimum extraction technology was as follows:the extraction time was 6.0 h, the soaking time was 2.0 h and the ratio of liquid to material was 12:1. The difference between the actual M value and the best M value of the model was 1%, which indicated that this experiment was had good predictability and the reliability of the model was high. CONCLUSION The optimum extraction technology based on response surface method and information entropy method can effectively improve the volatile oil content of Artemisia argyi.