Abstract: OBJECTIVE To establish a method for the dissolution curves in vitro, evaluate the similarity between original and generic drugs, improve the consistency and the level of medical service. METHODS Draw the dissolution curve of the original drug research different dissolution conditions of medium. Used ƒ₂factor method to evaluate generic and original drugs similarity. RESULTS Eleven domestic furosemide tablets and reference preparations could not meet the requirements of ƒ₂ factors in 5 dissolution curves, all of which were >50. CONCLUSION There is a big difference between the dissolution curves of generic and the original furosemide tablets, which does not conform to evaluation requirements, suggesting that the formulation and production process of generic furosemide need to be improved.