Abstract: OBJECTIVE To analyze the rules of medicinal groups that doctors treat patients with coronary heart disease using sodium tanshinone ⅡA sulfonate injection. METHODS Drug information of patients with coronary heart disease who used sodium tanshinone ⅡA sulfonate injection from hospital information system of Traditional Chinese Medicine Hospital of Kunshan were collected. Then used frequency statistics and association rules to evaluate the high-frequency drugs and sodium tanshinone ⅡA sulfonate injection combined medication. RESULTS In clinical real world use, the patients with coronary heart disease treated with tanshinone ⅡA sodium sulfonate injection, and the average median of drug use was 7 kinds. The main single combination drugs were aspirin enteric-coated tablets(73.94%), alprostadil injection(45.28%), atorvastatin calcium tablets(42.35%) and so on. In addition to aspirin enteric tablets, the other two commonly used combinations were atorvastatin calcium tablets+hydroclopidogrel tablets(55.331%) and hydroclopidogrel tablets+edaravone injection(42.279%). The correlation analysis of multiple combined drug use showed that sodium tanshinone ⅡA sulfonate injection was used in the treatment of coronary heart disease with aspirin enteric-coated tablets, pantoprazole sodium injection, hydroclopidogrel tablets, atorvastatin calcium tablets and edaravone injection. CONCLUSION Sodium tanshinone ⅡA sulfonate injection in the treatment of coronary heart disease patients with basic conform to the requirements of the guidelines. However, attention shall be paid to the benefits and risks of drugs with similar efficacy or the combination of Chinese and western medicines, so as to reduce the compatibility harm.