Abstract: OBJECTIVE To provide reference for the individualized treatment of severe thrombocytopenia and venous thromboembolism after chemotherapy. METHODS The pharmacist was involved in the anticoagulation treatment for a patient with severe thrombocytopenia and venous thromboembolism of lower extremity after chemotherapy. The individualized service of the selection of anticoagulant drugs, dosage and prevent related adverse were provided. RESULTS The patient's platelet returned to normal, venous thrombus disappeared and there was no bleeding occurred. CONCLUSION Clinical pharmacist can improve effectiveness and safety in the treatment of patient with severe thrombocytopenia and venous thromboembolism by providing individualized drug treatment.