Abstract: OBJECTIVE To explore the role that enhanced recovery after surgery(ERAS)-based multidisciplinary management proposed by clinical pharmacists plays on the prevention and treatment of urinary sepsis associated with gynecological malignancy surgery. METHODS One hundred and nine patients who were planted and removed indwelling ureteral stents due to operations of gynecologic malignant tumors from July, 2017 to December, 2018 in Chongqing Health Center for Women and Children were selected. Patients were randomly divided into the experimental group(55 patients) and the control group(54 patients) and given the multidisciplinary management approach and the routine medical treatment respectively. The two groups were compared in terms of the incidence of urinary sepsis, postoperative complications, incidence of adverse drug reactions, clinical costs, hospitalization days and use of antibiotics. RESULTS The experimental group showed lower results in clinical costs for the two operations, western medicine costs, antibiotics costs, incidence of urinary sepsis, and the incidence of adverse drug reactions than the control group. The experimental group also abbreviated the treatment courses of antibiotics in the two operations, and the difference was statistically significant(P<0.05). Escherichia coli producing extended-spectrum β-lactamases was an important pathogenic bacterium of urinary sepsis. CONCLUSION ERAS-based multidisciplinary management proposed by clinical pharmacists will help minimize the urosepsis risks caused by indwelling or taking out stent, which comes as a supplement to ERAS-based gynecological malignancy medication management and work of clinical pharmacists.