Abstract: Zebrafish(Danio rerio), as an emerging vertebrate model animal, is widely used in the research of various diseases, such as cardiovascular diseases, central nervous system diseases, kidney diseases and so on. Zebrafish's genes are highly homologous with human's. What's more, zebrafish is featuring in vitro fertilization, in vitro development in embryonic period and body transparency, etc. The models based on zebrafish has greatly promoted the basic research in the medical field. This review present the research progression in Alzheimer's disease(AD) and applications of the zebrafish models of AD in recent years. New ideas for the applications of zebrafish in the development and research of new drugs for AD are also provided.