Abstract: Solid dispersion(SD) is an effective way to improve the solubility, dissolution behavior and bioavailability of insoluble drugs. However, the poor stability of SD has become the bottleneck problem restricting the marketization of drug delivery system based on solid dispersion technology. The effects of process factors such as preparation method, preparation technology and storage conditions on the stability of SD recrystallization, drug composition content, dissolution and appearance are discussed, which provides guidance for SD research and development.