Abstract: OBJECTIVE To investigate the feasibility of voice quick response code for drug use guidance in children, so as to reduce the rate of drug consultation, ensure the rational drug application. METHODS Collected drug consultation questions and conducted statistical analysis. With this as a guide, the voice quick response(QR) labels was developed through the live code management system, and the medicine with more consultations was selected for trial and evaluation. RESULTS From January 2017 to December 2018, a total of 959 drug consultation problems were collected, mostly by telephone. More than 80% of the problems were belong to type Ⅱ(rational use of drugs). With the use of voice QR code labels, the access rates of clarithromycin dry suspension, ibuprofen suspension, oral rehydration salts and montmorillonite powder were 65.53%, 58.32%, 49.86% and 48.44%. The number and rate of drug consultants were decreased significantly(P<0.01). The satisfaction rate of patients with voice QR code labels was 97.50%. CONCLUSION The voice QR code of drug labels based on the "Internet+ medication guidance" mode is suitable for children. It is feasible and can be extended to more patients or drugs.