Abstract: Promyelocytic leukemia protein(PML) is a tumor suppressor that involved in the regulation of various biological processes such as cell apoptosis, cell senescence, and DNA repair. In several type of tumors, PML protein was found to be significantly down-regulated, indicating that it plays an important role on preventing tumor formation. Although there are many literatures focusing on the molecular mechanism of PML protein in regulating the development of malignant tumors, but it has not been systematically summarized. In this review, the current research status, and comprehensively summarize the effect of PML protein on tumorigenesis including the regulation of cell apoptosis, cell proliferation, cell migration and metastasis, cellular senescence, and angiogenesis was analyzed. In order to provide a new idea for treatment of related malignant tumors.