Abstract: OBJECTIVE To investigate the syndrome differentiation regularity, key points and precautions of recommended Chinese patent medicine by analyzing the diagnosis and treatment protocols for COVID-19, so as to provide references for clinical rational drug use. METHODS Excel software was used to input the disease stage, syndrome type, treatment, Chinese patent medicine information from the diagnosis and treatment protocols for COVID-19 published by National and Regional Health Authorities, and analyze the frequency of Chinese patent medicine using in different stages and types of diseases. Summarize the classification, contraindication and precautions of Chinese patent medicine. RESULTS A total of 23 diagnosis and treatment protocols for COVID-19 used Chinese patent medicine were recommended. Seventy-three kinds of Chinese patent medicine were recommended, and they were mainly divided into 9 categories according to their functions, the most were heat clearing drugs. Twenty-four instructions of Chinese patent medicine marked the contraindications, mainly involving pregnant or nursing women, infants, the elderly and patients with basic diseases. There were 18 Chinese patent medicines recommended for children. Seven of them were pediatric specialties and twelve of them mentioned dosage for children. Ten kinds of traditional Chinese medicine injections were recommended, which all had strict requirements for the selection of solvents, dropping speed and interval flushing for combined drugs. CONCLUSION Chinese patent medicines plays an important role in diagnosis and treatment for COVID-19. The correct dialectical and rational use of Chinese patent medicine is the key to give full play of its curative effect and ensure its safety.