Abstract: The public health events such as the COVID-19 epidemic situation affected of the clinical trials carried out in hospitals. During the period of COVID-19 epidemic situation, the department of clinical trail institutions of the First Affiliated Hospital, College of Medicine, Zhejiang University, had taken a series of management to ensure the safely and effectively development of clinical trials. They adjusted the arrangements of clinical trial by optimizing the workflow, and carried out the new clinical trials related to COVID-19. Herein, the experience of the management in good clinical practice during the period of COVID-19 epidemic situation was summarized, and to provide reference and suggestions for the management of clinical trials under public emergencies.