Abstract: OBJECTIVE To analyze the outpatient prescriptions of metabolic interactions between clarithromycin and statins, and promote rational drug use. METHODS Outpatient prescriptions of using clarithromycin in combination with statins from January 1, 2017 to December 31, 2018 through rational drug software system in a hospital were surveyed. Based on the Micromedex database of drug interactions, potential drug-drug interactions(pDDIs) were identified and classified into categories of potential clinical outcome. The case reports of adverse reactions between clarithromycin and statins were collected from CNKI, VIP, Wanfang and PubMed and analyzed. RESULTS A total of 41 prescriptions of clarithromycin combined with statins were enrolled. There were 30 prescriptions for pDDIs, including 24 atorvastatin prescriptions and 6 simvastatin prescriptions. The severity level of pDDIs was determined by Major(B). Twelve cases of adverse reactions caused by interaction between clarithromycin and statins were included. In which, 11 cases occurred rhabdomyolysis. CONCLUSION There are pDDIs between clarithromycin and statins in the hospital, and simvastatin showed overdose medication. It is necessary for hospital to strengthen monitoring and intervention to reduce the risk of medication.