Abstract: OBJECTIVE To explore the rational application and pharmaceutical care of traditional Chinese medicine in the treatment of COVID-19. METHODS Taking the traditional Chinese medicine of the COVID-19 Diagnosis and Treatment Plan (the Seventh Edition for Trial) as the research object, the inductive analysis was carried out according to the drug instruction manual, the theory of traditional Chinese medicine, modern pharmacological research and clinical literature reports. RESULTS Through a detailed reading of the medical guidelines for Chinese medicine, it was found that the lack of Chinese medicine in the actual clinical use of the precautions, and the Chinese medicine involved may have adverse reactions to special groups or combination drug therapy. CONCLUSION The collated information about the precautions of traditional Chinese medicine and the drug interactions when used in combination, can provide reference for clinicians to treat COVID-19.