Abstract: OBJECTIVE To investigate the application of gonadotropin-releasing hormone agonist(GnRHa) in endometriosis and analyze the efficacy of different GnRHa. METHODS Using the hospital computer prescription management system to transfer the prescription information of GnRHa in the outpatient pharmacy from January 1, 2018 to January 1, 2019. The proportion of patients with endometriosis treated with leuprolide, goserelin, triptorelin was analyzed, and the effects of different GnRHa on abnormal uterine bleeding, intimal thickness and CA125 were studied. RESULTS The use ratio of leuprolide goserelin, tri-ptorelin in endometriosis was 29.45%, 46.52%, and 24.03%, respectively. There was no significant difference in thickness of endometrium, uterine volume and CA125 before and after treatment with different GnRHa; the number of irregular uterine bleeding was the highest in triptorelin and the lowest in leuprolide. CONCLUSION There is no significant difference in the efficacy of different GnRHa. The reasons for the high or low proportion of GnRHa may be related to the safety, economy of drug, regionality and habits of doctor.