Abstract: OBJECTIVE To explore the rules of traditional Chinese medicine for prevention and treatment of COVID-19 based on association rules, factor analysis and cluster analysis, in order to provide reference for COVID-19 clinical prevention and treatment of traditional Chinese medicine. METHODS From late January 2020, when TCM interventional COVID-19 treatment was started, the Chinese medicine treatment plans given by various regions and famous doctors in the country were collected. The dietary and sachet prescriptions were excluded, only the preventive and therapeutic prescriptions were collected, and established a database for statistical analysis. Used the 2015 edition of the Chinese Pharmacopoeia to classify the medicinal properties of traditional Chinese medicines. Used Excel 2016, Clementine 12.0, SPSS Statistics 21.0 statistical software to analyze association rules, factor analysis and cluster analysis of the included Chinese medicines. RESULTS A total of 101 prescriptions, 163 flavors of traditional Chinese medicine, and a frequency of 974 occurrences were included in this statistic. Among the 101 prescriptions included in the database: 28 kinds of Chinese medicines with a frequency of ≥10 and 14 kinds of Chinese medicines with a frequency of ≥15. The top three drugs with the highest frequency were licorice, honeysuckle and forsythia. Over all, the efficacy and classification of antipyretics, tonics and antihypertensive drugs were the most common. Among nature and flavor, and channel tropism, there were cold in nature, warm in nature, and neutral in nature. The bitter, sweet and astringent flavors account for 96.91% of the total medicinal flavors, and the meridians were attributed to the lung, stomach and spleen mainly. Nine couplet medicines combinations with the highest correlation strength were obtained through the association rule analysis. Five factors were obtained through factor analysis. And three clusters were extracted through cluster analysis. CONCLUSION The traditional Chinese medicine for the prevention and treatment of COVID-19 is mainly heat-clearing medicine, and combined with tonic and antipyretic drugs can have a good effect in preventing and treating diseases.